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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ESR1 All Species: 18.48
Human Site: S305 Identified Species: 50.83
UniProt: P03372 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P03372 NP_000116.2 595 66216 S305 I K R S K K N S L A L S L T A
Chimpanzee Pan troglodytes XP_001170268 530 59089 A275 L V L T L L E A E P P H V L I
Rhesus Macaque Macaca mulatta Q9TTE5 279 31087 L33 L S P E Q L V L T L L E A E P
Dog Lupus familis XP_533454 596 66219 S306 I K H T K K N S P A L S L T A
Cat Felis silvestris
Mouse Mus musculus P19785 599 66936 S309 I K H T K K N S P A L S L T A
Rat Rattus norvegicus P06211 600 67011 S310 I K H T K K N S P A L S L T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P06212 589 66728 S299 V K H N K K N S P A L S L T A
Frog Xenopus laevis P81559 586 66062 S297 S V K S M K L S P V L S L T A
Zebra Danio Brachydanio rerio P57717 569 62828 V273 K K R S G G V V S T L C M S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 44.3 29 90 N.A. 88.9 88.1 N.A. N.A. 78.1 69.9 48.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 64 38.8 94.8 N.A. 93.4 92.8 N.A. N.A. 86.8 81.6 63 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 6.6 80 N.A. 80 80 N.A. N.A. 73.3 53.3 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 26.6 20 86.6 N.A. 86.6 86.6 N.A. N.A. 86.6 60 40 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 12 0 56 0 0 12 0 67 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 12 0 0 12 0 12 0 0 12 0 12 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 12 12 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 45 0 0 0 0 0 0 0 0 12 0 0 0 % H
% Ile: 45 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % I
% Lys: 12 67 12 0 56 67 0 0 0 0 0 0 0 0 0 % K
% Leu: 23 0 12 0 12 23 12 12 12 12 89 0 67 12 0 % L
% Met: 0 0 0 0 12 0 0 0 0 0 0 0 12 0 0 % M
% Asn: 0 0 0 12 0 0 56 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 12 0 0 0 0 0 56 12 12 0 0 0 23 % P
% Gln: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 23 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 12 12 0 34 0 0 0 67 12 0 0 67 0 12 0 % S
% Thr: 0 0 0 45 0 0 0 0 12 12 0 0 0 67 0 % T
% Val: 12 23 0 0 0 0 23 12 0 12 0 0 12 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _